There are several cases reported in the literature on the impacts of benztropine administration during pregnancy. The effect of benztropine during pregnancy and labor is still unknown. Consequently, it is safe to contraindicate benztropine during breastfeeding as a cautionary measure. However, in general, certain studies of antimuscarinic drugs proved that they harm animal breastfeeding since they reduced the serum prolactin concentration in the experimental animals. Moreover, atropine (which is structurally similar to benztropine) has little to no effect on human breastfeeding as a general. There are not enough studies in the literature that define the exact effects of benztropine on human breastfeeding, so it is unknown whether it is excreted in human milk. Therefore, benztropine is contraindicated in children under the age of three years, infants, and neonates. Usually, pediatric patients are relatively more sensitive to anticholinergic agents. The IV route should be reserved for drug-induced extrapyramidal symptoms or whenever oral and IM administration are unsuitable. There is no significant clinical difference in the action onset of benztropine between intramuscular or intravenous administration.īenztropine Mesylate is available as a 1 mg per mL injection for IV administration. It can be administered orally with no specific regard for meals. The oral route is preferable to address initial and acute symptoms of drug-induced Parkinson. Benztropine therapy may start with the lowest initial dose of 0.5 mg and may increase up to 6 mg over a period of 5 to 6 days. Benztropine has cumulative action, so the dose should gradually be increased by 0.5 mg until optimal results are obtained without excessive adverse reactions.īenztropine mesylate is available as a 1 mg per mL injection for IM administration. īenztropine mesylate is available as 0.5 mg, 1 mg, and 2 mg strengths for oral administration. Each route has a particular advantage according to its specific indication. Benztropine is administered through oral, intravenous, and intramuscular routes.
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